Antigout Agents/Nutrient Depletion:
- Beta-caroteneBeta-carotene: Based on in vitro evidence, colchicine may cause disruption of intestinal mucosal function (10754268), theoretically resulting in malabsorption of beta-carotene.
- CopperCopper: Based on animal study, penicillamine use may be associated with increased excretion of copper (1732476).
- Folic AcidFolic Acid: In humans, the folate nutriture of patients taking low dose methotrexate declined without folic acid supplementation (9517760).
- IronIron: A human study showed reductions in oral penicillamine absorption by food, antacid, and ferrous sulfate(6831825).
- MagnesiumMagnesium: A human study showed reductions in oral penicillamine absorption by food, antacid, and ferrous sulfate(6831825).
- NiacinNiacin: In humans, the principal causes of pellagra (niacin deficiency) include: nutritional niacin deficiency, chronic alcoholism, gastrointestinal malabsorption, some medications (5-fluorouracil, isoniazid, pyrazinamide ehtionamide, 6-mercaptopurine, hydantoins, phenobarbital and chloramphenicol) (16207585).
- PotassiumPotassium: According to secondary sources, colchicine may impair absorption of potassium.
- Pyridoxine (vitamin B6)Pyridoxine (vitamin B6): Based on a review, penicillamine may be an antagonist of pyridoxine (4555929).
- RiboflavinRiboflavin: Based on human evidence, probenecid may modulate the absorption of riboflavin from the digestive tract and increase urinary excretion (5440673, 6049701).
- SodiumSodium: According to secondary sources, colchicine may impair absorption of sodium.
- Vitamin B12Vitamin B12: Colchicine may interfere with vitamin B12 in the body, although research is inconsistent (2823139). Based on lab study, colchicine may disrupt normal intestinal mucosal function (10754268), leading to malabsorption of several nutrients, including vitamin B12.
- ZincZinc: Based on animal study, penicillamine use may be associated with increased excretion of zinc (1732476).
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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.